Sentinel Spectrum

 This prescription medication requires a current annual visit to a Penny Paws clinic. We also require a current annual heartworm test for canine medication containing heartworm preventive.

All 6-month supplies of Sentinel Spectrum are out of stock.


What is Sentinel Spectrum? 
Simplify your dog's heartworm and flea protection with Sentinel Spectrum, the only beef-flavored chewable to protect against 6 parasites. Given monthly, Sentinel Spectrum prevents heartworms and prevents and controls fleas. Each chew also treats and controls whipworms, hookworms, roundworms, and tapeworms.

Dogs (over two pounds and six weeks of age and older)
Dogs love the delicious beef-flavored chewable
Prevents heartworms
Prevents and controls fleas
Treats and controls common intestinal parasites (whipworms, hookworms, roundworms and tapeworms)
Simple once-a-month administration
No messy residue to worry about, unlike spot-on treatments

How it works: 
Milbemycin oxime, lufenuron, and praziquantel are the active ingredients in Sentinel Spectrum which work to control fleas, major intestinal worms, and heartworms. Sentinel Spectrum contains an insect growth regulator (IGR) which kills flea eggs preventing them from hatching into adult fleas


Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating offspring (microfilariae). These reactions are presumably caused by release of protein from dead or dying offspring.


Do not use in puppies less than six weeks of age. Do not use in dogs or puppies less than two pounds of body weight. The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females.

More Information:
Brand Name
Sentinel Spectrum 

Active Ingredient(s):
Milbemycin oxime, lufenuron, and praziquantel.

What is this product used for:
Sentinel Spectrum is indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations; and for the treatment and control of adult roundworm, adult hookworm, adult whipworm, and adult tapeworm infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

How is Sentinel Spectrum administered:
Sentinel Spectrum should be given once a month, every month of the year. Preferably, Sentinel Spectrum should be given on the same date each month.

To ensure complete absorption, always give Sentinel Spectrum chewables to dogs either with or immediately after a normal meal. Food is essential for proper absorption of the product into the bloodstream. 

Most dogs like the taste of the Sentinel Spectrum chewable and will accept the chewable readily as a treat. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow the medication without chewing. The chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

How this product should be used:
Sentinel Spectrum should be administered orally, once every month with dosing based on your dog's weight. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes. 

What special precautions are there:
Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Sentinel Spectrum, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Sentinel Spectrum is not effective against adult D. immitis. 

Do not use in puppies less than six weeks of age. Do not use in dogs or puppies less than two pounds of body weight. The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females. 

What other drugs will affect Sentinel Spectrum:
While Sentinel is safe to use in dogs at risk for MDRI-allele mutation (Australian Shepherds, Collies, Shelties,etc.), unless tested normal, caution is advised if the pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erthromycin (Ery-Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Adlactone), tamoxifen, and verapamil (Calan). Do not give Sentinel Spectrum to your pet if already giving an alternate heartworm medication. 

How should I store this product:
Store in a dry place at controlled room temperature, between 59° and 77°F (15–25°C).

Click here to access the Sentinel Spectrum rewards program.

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